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Evidence Synthesis and
Summaries of Comparative Effectiveness & Safety
Cedar Associates LLC
conducts systematic reviews of medical literature according to the standards
expected from major stakeholders (e.g., see guidelines published for AHRQ’s
Evidence-Based Practice Centers). Our staff retrieves pertinent publications
(using PubMed, Embass, SciSearch) and abstracts from international congresses.
We also rely on clinical and economic experts to fill in potential gaps
associated with using electronic databases. Publications are then reviewed for
relevance to the project, and information is coded and abstracted into our
proprietary software. All studies are graded for the quality of the evidence
according to accepted quidelines. We generate evidence reports that have been
submitted use in AMCP dossiers and NICE submissions, and for reports to
regulatory agencies, clinical investigators, and senior managers.
Current and
Recent Projects
Efficacy and safety of treatments for eye diseases
We
abstracted more than 300 studies of treatments for diabetic macular edema,
retinal vein occlusion, and age-related macular edema. Reports were generated
on the incidence of adverse effects associated with existing treatments for
these conditions and effect on visual acuity by ETDRS criteria of treatments.
This evidence is being used in reports to FDA.
Efficacy and safety of chemotherapy regimens for colorectal cancer
We
abstracted all studies reporting findings from randomized controlled studies of
chemotherapy for colorectal cancer. This evidence has been used to provide a
comprehensive of the current state of the evidence in this area and to
instantiate parameters in cost-effectiveness studies.
Summary of Cost-effectiveness Studies in HIV/AIDS
More
than 100 studies have been published on the cost-effectiveness of various
interventions to prevent and manage HIV/AIDS. We systematically retrieved and
summarized these studies, the results of which are to be published soon in
Medical Decision Making.
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